New video: How we investigate mini-lungs in the CLARITY lab
Watch our new animation about how we investigate mini-lungs in the CLARITY lab
How our lung organoid models may contribute to finding preventive medicine, can be explained in four steps:
🔵 Build two lung organoid models: one with a genetic predisposition for asthma and one without, using the gene editing technique CRISPR-Cas.
🔵 Add different building blocks of RSV (from high or low-risk viruses) to both models.
🔵 Use a microscope to observe the damage in the lung cells caused by the virus at a highly detailed level, such as increased mucus production, cell death, increased levels of signaling proteins (cytokines).
🔵 Test whether (existing) medicine can prevent this damage in the models.
As part of the RSV Awareness Week 2025, organised by our partner ReSViNET, we share a new animation video that shows this process in more detail.